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Clinical References

What's New

  • Jul 2025Goal Regimen Builder: replaces Goal Volume Calculator with full regimen output and copy support.
  • Jul 2025Workspace improvements: 7-day idle expiry and storage-failure visibility added.
  • Jul 2025Input validation: per-module inline errors and copy gating across all calculators.

This tool is provided for clinical reference and educational purposes only and is not intended to guide or replace medical decision-making. It does not substitute for professional judgment, institutional protocols, or individualized patient assessment. Users assume full responsibility for verifying all calculations and applying them in clinical practice.

Browse calculators

Formula Recipe Generator

Mixing calculator and PNPG discharge recipes for infant formulas and fortified EBM.

Formula or EBM

Modulars

Detailed Nutrient View

Formula & Feeding Schedule

Modulars

Free Water & Flushes

Detailed Nutrient View

Goal Regimen Builder

Total volume/day
Rate
Enter a calorie goal and formula to build a regimen.

Total volume = calorie goal ÷ formula caloric density. Maintenance fluid uses the Holliday-Segar method; free-water flush volume is derived from the selected pediatric formula's free-water content (not available for infant formula, breast milk, or fortified breast milk).

Input Parameters

With workspace Sync on, the plan follows the active regimen's achieved kcal/kg/day; Infant Feeds also supplies feeds/day for bolus schedules and kcal/oz. Growth goal uses the top of the chronological-age term band from the Growth Velocity Reference. These derived values can be manually overridden until the next workspace or regimen sync.

Advancement Schedule

DateWeight (kg)kcal/daymL/dayRegimen

Weight Gain / Date Calculator

Days between
Total weight change
Rate of change
Copy Summary
Enter both dates and weights to see a summary.

Growth Velocity Reference

Infants & Toddlers (0-24 months)

AgeWeight (g/d)Height (cm/wk)Head circumference (cm/wk)

*Preemie rows are reported in g/kg/d (per kilogram of infant weight), not absolute g/d like the other rows.

Children (2-11 years)

AgeWeight (g/d)Height (cm/month)

Growth Percentile Calculator (WHO/CDC)

Growth Chart

Plots the current Growth Percentile Calculator result against the same WHO/CDC percentile reference curves used by the calculator above. A single-point companion view only -- it does not accumulate or persist measurements across sessions.

Corrected Gestational Age (CGA) Calculator

Chronological age
Corrected gestational age
Corrected age (from EDD)
Chronological age (months)
Corrected gestational age (months)
Corrected age (months)
Estimated due date
GA at birth
Preterm (<37 wk)
Enter gestational age at birth, date of birth, and the as-of date to calculate corrected age.

Corrected gestational age (postmenstrual age) = gestational age at birth + chronological age. Corrected age = corrected gestational age − 40 weeks, referenced to the estimated due date — the figure used for growth charts and developmental milestones. Per standard AAP/WHO/CDC convention, age correction for prematurity (GA <37 weeks) is typically applied through 24 months chronological age; beyond that, chronological age is used uncorrected. These are population-level conventions, not a substitute for clinical judgment.

Formula Mixing

Calculation follows PNPG methodology: final volume = liquid volume + (powder grams × displacement mL/g), converted to oz. Recipes assume unpacked scoops/measures unless the formula is normally packed.

Recipe Generator (Computed + PNPG Reference)

PNPG Reference

Small Batch

Select options above to see the small-batch recipe.

Large Batch

Select options above to see the large-batch recipe.

Formula-only small-batch outputs are computed from the PNPG “Values for Infant Formula: Powders” mixing data. Published PNPG recipe rows remain visible as labeled references. Cup-batch and fortified-EBM guidance remain PNPG-table-only because verified grams-per-cup data are not available.

Calculation mode

Manual recipe entry and goal-based recipe generation use the same forward analysis.

Recipe inputs

Used for per-kilogram values.
Water added apart from liquid ingredients.

Ingredients

Powders use grams and liquids use mL. Ingredient volume includes registered powder displacement and liquid volume.

Detailed nutrient view

NutrientTotalPer kgElectrolyteCoverage
Show all other nutrients
NutrientTotalPer kgElectrolyteCoverage

Formula & Feeds

Daily calories (formula)0 kcal
Total LCT0 g
Total omega-6 (linoleic acid)0 g
Total omega-3 (ALA)0 g
Total essential fatty acids (formula only)0 g

Walnut Oil Modular

Walnut oil LCT0 g
Walnut oil omega-60 g
Walnut oil omega-30 g
Walnut oil calories0 kcal

Totals & Adequate Intake

0
total LCT g/day
0
total EFA g/day
0
total kcal/day

Adequate Intake for Age

AI age bracket matched
AI omega-6 for age— g/day
AI omega-3 for age— g/day
% of AI met — omega-6
% of AI met — omega-3
% of daily calories from omega-6 (linoleic acid)
% of daily calories from omega-3 (ALA)

GIR Calculator

mg/kg/min (GIR)
Dextrose/day
Rate used
Enter weight, rate/volume, and dextrose % to calculate GIR.

PN Parameters

Substrates

Selection identifies the stock solution and includes only labeled intrinsic contributions available in the worksheet dataset. It does not recommend a product.

Electrolytes & Additives

Allocate sodium and potassium among chloride, acetate, and phosphate products. The worksheet reports the resulting elemental and counterion totals; it never auto-selects a salt.

Elemental totals

Enter additive amounts.

Counterion totals

Enter additive amounts.

ELCYS / cysteine-

Cysteine guidance

Published compatibility screen

Advisory only

The published dataset applies to 2-in-1 formulations only. 3-in-1 calculations remain available, but their compatibility is not assessed by this screen.

No applicable published compatibility envelope. Pharmacy verification required.
Published calcium-phosphate boundaryChart will appear when an exact published dataset matches the worksheet conditions.

Dataset conditions are not yet matched.

Dextrose provides 3.4 kcal/g, amino acids provide 4 kcal/g. Lipid emulsion caloric density: SMOF 20% and Intralipid 20% provide 2.0 kcal/mL; Omegaven 10% provides 1.12 kcal/mL. Cysteine HCl is estimated at 40 mg per gram of amino acids. Nitrogen is estimated as amino acid grams divided by 6.25. Osmolarity is an estimate using component concentration factors and excludes cysteine and lipid; verify the final admixture with pharmacy compounding calculations. ASPEN recommends peripheral PN remain below 900 mOsm/L; formulations above 900 mOsm/L should use central access. A formulation at exactly 900 mOsm/L requires pharmacy confirmation.

ASPEN PN Dosing References

ASPEN 2019

Macronutrient dosing

PopulationProtein initiationProtein goalDextrose initiationDextrose goalLipid initiationLipid goal

Electrolyte dosing

PopulationSodiumPotassiumCalciumPhosphorusMagnesium

Multivitamin dosing

ConventionWeight bandDose

Trace-element dosing

PopulationZincCopperManganeseChromiumSelenium
Source Citation

Source: ASPEN Recommendations on Appropriate Parenteral Nutrition Dosing for Neonatal and Pediatric Patients, American Society for Parenteral and Enteral Nutrition (ASPEN), 2019, rev. 1.8.19. These are population-level dosing references and do not replace institutional protocol or individualized clinical judgment.

Weight

Type into either field of a pair — the other updates automatically. A conversion utility only; no calculation logic and no workspace Sync integration.

Length

Volume

Energy

Electrolytes (mg ↔ mEq)

mEq = mg × valence ÷ atomic weight (Na 22.99, K 39.10, Cl 35.45, Ca 40.08, Mg 24.31; Ca and Mg are divalent).

Phosphorus (mg ? mmol)

Phosphorus is reported in mmol rather than mEq — physiologic phosphate's valence varies with pH (a mix of HPO4²⁻/H2PO4⁻), so it has no single fixed mEq equivalence. mmol = mg ÷ 30.97 (elemental phosphorus atomic weight).

Vitamin D (mcg ? IU)

1 mcg = 40 IU (cholecalciferol/ergocalciferol; form-independent). Source: NIH Office of Dietary Supplements.

Vitamin E (mg ? IU)

Potency differs by form: natural (RRR-/d-alpha-tocopherol) 1 mg = 1.49 IU; synthetic (all-rac-/dl-alpha-tocopherol) 1 mg = 1.10 IU. Select the form the product actually uses — the two are not interchangeable. Source: NIH Office of Dietary Supplements.

Vitamin A (mcg retinol ? IU)

1 mcg preformed retinol (or retinyl ester) = 3.33 IU. Applies to preformed vitamin A only — beta-carotene and other provitamin-A carotenoids convert at different, food-source-dependent ratios not implemented here. Source: NIH Office of Dietary Supplements.

Formula information comes from product-specific source documents; verification status and dates are shown in Data Sources. This library is provided for clinical reference only; verify current product labeling and institutional guidance before applying values in clinical practice.

Micronutrient Reference Tables

Dietary Reference Intakes and Tolerable Upper Intake Levels by life-stage group. Values are shown with the units and source markers supplied in the reference files.

Dietary Reference Intakes (DRIs)

Elements

Vitamins

Tolerable Upper Intake Levels (ULs)

Elements

Vitamins

Source Citation

Age-Based Energy & Protein Needs

DRI kcal/kg/d
BMR kcal/kg/d
g protein/kg/d
Total energy (DRI × weight)
Total energy (BMR × weight)
Total protein (g/d)
Estimated energy

Estimated Needs Readout


          

Source: Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition (updated June 2025). DRI = Dietary Reference Intake; BMR = basal metabolic rate. For infants 0-2 months, DRI/BMR are not established on this reference — protein target only. The activity factor range is a manual what-if multiplier applied to BMR (not a value from the source reference).

Critically Ill Protein Needs

Protein need
Total protein (g/d)

Source: Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition. Applies to critically ill pediatric patients; use in place of standard age-based DRI protein targets when clinically indicated.

Fluid Requirements — Holliday-Segar Method

0
mL/day
0
mL/hr
Enter weight to see the Holliday-Segar calculation.

Holliday-Segar Tiers

Weight bandFluid formula
1-10 kg100 mL/kg
11-20 kg1000 mL + 50 mL/kg for each kg >10 kg
>20 kg1500 mL + 20 mL/kg for each kg >20 kg

Source: Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition. Holliday-Segar tiers: 1-10 kg = 100 mL/kg; 11-20 kg = 1000 mL + 50 mL/kg for each kg >10 kg; >20 kg = 1500 mL + 20 mL/kg for each kg >20 kg.

Catch-up Growth Needs

Catch-up energy need
Total energy (kcal/d)

Formula: kcal/kg/d = [IBW (kg) × DRI (kcal/kg/d for age)] ÷ actual weight (kg). IBW is based on weight-for-length ratio for infants. Source: Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition.

Preterm Infant Needs (VUMC NICU Protocol)

Energy
Energy need110-130 kcal/kg/d
Total energy (kcal/d)
Protein
Protein need
Total protein (g/d)

Source: Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition, Vanderbilt University Medical Center (VUMC) NICU Protocol. The energy target (110-130 kcal/kg/d) applies across all preterm birth-weight bands; the protein target varies by birth weight.

Texas Children's Hospital Pediatric Nutrition Reference Guide, 13th edition — updated June 2025. Not all reference tables from the source sheet are included here (developmental-disability energy methods and the pediatric malnutrition tool are not yet built into this page).

Workspace Sync

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